Assistant Adjunct Professor
Department of Bioengineering and Therapeutic Sciences
University of California San Francisco
PGRN Group: PMT
A member of the PMT group since 2007, Dr. Sook Wah Yee is currently Assistant Adjunct Professor in the Department of Bioengineering and Therapeutic Science at University of California San Francisco. In collaboration with other PMT investigators, Dr. Yee has made a number of discoveries related to membrane transporters. Notably, she and her colleagues discovered that ABCG2 (Breast Cancer Resistance Protein, BCRP) is a key transporter involved in the disposition and response to the anti-gout medication, allopurinol. Genetic variants in this transporter associated with poor response to allopurinol. Other discoveries include the finding that transporters for the world’s most widely prescribed anti-diabetic drug, metformin, also transport vitamin B1, thiamine. Sook Wah is actively involved in many collaborative studies to identify membrane transporters that modulate drug response and human traits. She is especially passionate about discovering new roles of membrane transporters in targeting drugs to tissues of interest to treat human diseases. She has participated in studies of genotype-to-phenotype, candidate gene and genome-wide association related to response to metformin and other highly transported drugs. In addition, she also devoted her time within PMT as Project Director, as well as, within the PGRN-RIKEN Network Resource and PGRN-RNASeq.