Debbie Nickerson is a professor of Genome Sciences at the University of Washington School of Medicine, Seattle, Washington, and runs the Northwest Genomics Center in Seattle. In collaboration with researchers accorss the country, the NHLBI Large-Scale DNA Sequencing Project, mines genetic data gathered from the NHLBI-funded population studies of heart, lung, and blood diseases. The Nickerson Lab is interested in the identification and typing of common sequence variations in the human genome known as single nucleotide polymorphisms (SNPs). By identifying SNPs they hope to gain an understanding of the patterns of sequence variation in human genome and to improve approaches for association mapping of common human diseases. They are also developing and testing novel SNP and haplotype-based approaches for association mapping in humans, and exploring the relationships that may exist between genotype and trait expression at the RNA and protein levels in humans.