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Featured PGRN Investigators

Wei-Qi Wei, MD, PhD

4/1/2018

 
Dr. Wei-Qi Wei is an assistant professor in the Department of Biomedical Informatics at Vanderbilt University Medical Center. Dr. Wei is a clinical informatician with a research focus on harvesting knowledge from big clinical and genetic data to enhance precision medicine, especially to improve drug safety. His current work includes deep phenotyping within big EHR data, developing resources to facilitate high-throughput phenotyping, machine learning on biomedical data, and investigating pharmacogenetic factors of common drugs. He is the creator of MEDI, a computable medication-indication resource.
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 Assistant Professor 
Biomedical Informatics
wei-qi.wei@vanderbilt.edu

 Full Profile 
Featured project: Exploring Statin Pleiotropic Effects within a Very Large EHR Cohort
Statins (HMG-CoA reductase inhibitors), among the most widely prescribed agents worldwide for prevention of cardiovascular diseases, produce substantial pleiotropic effects. Pleiotropic effects are unanticipated outcomes other than those for which the drug was originally developed, either therapeutic (beneficial) or detrimental (adverse drug reactions). Statin pleiotropic effects are unanticipatedly broad, including increasing the risk of developing type 2 diabetes mellitus (T2DM), decreasing cancer-related mortality, and reducing dementia. Many effects are still not determined. In addition, individual responses to statins are highly variable. In this project, we investigate statin pleiotropic effects using whole de-identified electronic health records (EHRs) of >2.5 million patients at Vanderbilt, including >100,000 statin recipients. We will evaluate genetic predictors of statin pleiotropic effects as well.

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  • Home
  • What is PGRN?
  • Members
    • Join
    • Members >
      • Member Research Interests
      • Members List
      • Members Directory
    • Apply for a Webpage
    • Research Pages >
      • African American Pharmacogenomics
      • Clinical Implementation of PGx
      • I-PICC: Integrating Pharmacogenetics in Clinical Care
      • Genetics of Israeli Populations (NLGIP)
      • GeT-RM PGx
      • Metformin PGx
      • MT-targeting agents
      • PGx of AIWG
      • PGx of Chemotherapeutic Toxicities
      • PGx of Statin Therapy
      • Precision Medicine In Leukemia
      • Predicting Drug Action
      • ...More Pages Coming Soon
    • Partner PGx Organizations >
      • UKPSMN
      • UPGx
    • Communities >
      • MetGen
    • Leadership
  • Data & Tools
    • GWAS Statistics >
      • RIKEN GWAS Statistics
    • Tools
  • PGRN Resources
    • Clinical Implementation
    • Functional Pharmacogenes
    • PGRN Hub
    • PGRN-PiLS Resource
    • PGRN-RIKEN >
      • RIKEN Publications
      • RIKEN Investigators
      • RIKEN Projects
    • PharmGKB
    • PharmVar
    • RPGEH
  • News
    • Event Calendar
    • PGX News
    • Featured Investigators
    • PGRN Recorded Talks
    • All PGRN Publications
  • Meetings
    • Monthly Member RIPS
    • All-Members Calls
    • Upcoming PGRN Meetings >
      • ASHG 2018
    • Past PGRN Meetings >
      • ASHG 2017
      • CPIC® Meeting 2017
      • ASHG 2016
      • Annual PGRN meeting at ASCPT 2016
      • 2015 PGRN All PIs Retreat
    • Other PGx Meetings
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