Upcoming PGRN events

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• Research in Progress - Katherine Theken, PharmD, PhD

  • When
    Fri, October 09, 2020
  •  
    8:00 AM - 9:00 AM (PDT)
  • Location
    Zoom - Members Only

  "Pharmacogenetics of NSAIDs: Using CYP2C9 Genotype to Guide Treatment"

  Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used drugs worldwide, but have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. Several drugs in this class are metabolized by CYP2C9, and polymorphisms in this enzyme that alter NSAID clearance may affect safety. This talk will summarize evidence supporting the association between CYP2C9 polymorphisms and NSAID exposure and discuss the recently published CPIC guidelines for usingCYP2C9 genotype to guide NSAID therapy.

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• PGRN Annual Meeting & Poster Session

  • When
    Mon, October 26, 2020
  •  
    9:00 AM - 1:00 PM (PDT)
  • Location
    Zoom

  Register

  Deadline for abstracts has been extended to 14 Sept.
  

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• Research in Progress - Laura Ramsey, PhD

  • When
    Fri, November 13, 2020
  •  
    8:00 AM - 9:00 AM (PST)
  • Location
    Zoom - Members Only

  "Pharmacogenetics of Antidepressants in Pediatric Patients with Anxiety and Depression"
  Dr. Ramsey is the Co-Director of the Genetic Pharmacology Service at Cincinnati Children’s Hospital Medical Center, which offers pharmacogenetic tests to patients and provides interpretation of results. She will present on the retrospective studies of pediatric patients with pharmacogenetic test results that were treated with antidepressants. Her lab found that pharmacogenetic phenotypes were associated with response, tolerability, and length of hospitalization in children with anxiety and/or depression treated with escitalopram, sertraline, and fluoxetine. They also performed pharmacokinetic modeling of escitalopram and sertraline based on CYP2C19 phenotypes to predict doses that would provide equivalent exposure across CYP2C19 phenotypes.

   

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• Research in Progress - Mary Relling, PharmD

  • When
    Fri, December 11, 2020
  •  
    8:00 AM - 9:00 AM (PST)
  • Location
    Zoom - Members Only

  
  

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• Research in Progress - Robert Plenge, MD, PhD

  • When
    Fri, January 08, 2021
  •  
    8:00 AM - 9:00 AM (PST)
  • Location
    Zoom - Members Only

  "Human Genetics and Drug Discovery"
  Robert Plenge, MD, PhD
  Sr. Vice President - Research & Early Development
  Bristol Myers Squibb

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