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PGx News

PharmVar.org replaces the Human Cytochrome P450 (CYP) Allele Nomenclature Database

9/26/2017

 
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After more than 15 years the Human Cytochrome P450 (CYP) Allele Nomenclature Database has transitioned...
​
... to the Pharmacogene Variation (PharmVar) Consortium at PharmVar.org
PharmVar will serve as a central repository for pharmacogene variation to facilitate allele (haplotype) designation and the interpretation of pharmacogenetic test results to guide precision medicine.
​
PharmVar is a PGRN resource funded by NIGMS.

After September 26, 2017, please visit PharmVar.org to access content of the original P450 Nomenclature Database

PGRN-Wide Member Call: PGRN Tools and Resources

9/14/2017

 
We had a good turn out at the last PGRN-Wide Member Call on September 8th.  Below are some key highlights from the call:
  • More than 38 posters will be presented at the coming 2017 PGRN-ASHG Open Poster and Reception, check out the posters titles here, www.pgrn.org/ashg-2017.html
  • You can register to attend the PGRN-ASHG Open Poster and Reception (October 19th) here. 
  • 2018 PGRN-ASHG meeting planning are on-going. More information will be posted soon at pgrn.org
  • Two new PGRN Resources were introduced during the call: PGRN-PILS Resource by Dr. Nao Terada, and PharmVar by Dr. Andrea Gaedigk. 
  • Dr. Nina Gonzaludo, a PGRN member, introduced the resource GeT-RM PGx, a pharmacogenetics reference material resource.  See more here www.pgrn.org/get-rm_pgx.html
  • Dr. Eric Jorgenson, a PGRN-Hub member, introduced the latest resource from UKBioBank, Gene ATLAS, geneatlas.roslin.ed.ac.uk/region/.  
  • More tools that are useful for pharmacogenomics research can be found here http://www.pgrn.org/tools.html.

Tools page: eQTL Databases

9/11/2017

 
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Expression quantitative trait loci (eQTL) are genetic variations that affect gene expression.  Several eQTL databases have been created to allow researchers to look up genetic loci that are associated with gene expression and in different types of tissues and cells.  In the pgrn.org Tools webapp, we curated several key eQTL databases, such as eQTL of the blood, intestine, immune cells, kidney, lung and monocytes.  The most popular eQTL database is GTEx Portal, which has measured transcription levels of genes in 53 tissues using RNAseq and also eQTL for 44 different tissues in over 7000 samples (ref).  The GTEx database allows users to view and download computed eQTL results (link).  The datasets serve as useful resource for additional kinds of analyses and it is widely used by researchers to inform the genetic association of their genomewide association studies (ref, ref, ref) or to validate findings from in vitro assays.  Below are a few examples that are valuable resources. Should you know of any eQTL databases, which are missing from the Tools webapp, please contact info@pgrn.org.  Please visit pgrn.org/tools to check out other tools.

PGRN-wide Member Call: Friday, Sept. 8, 2017 at 11 am Pacific

9/6/2017

 
We will host our second PGRN-wide member call on Friday, September 8, 2017 at 11:00 am Pacific time via Webex (1:00 pm Eastern time). The agenda for the call can be found on the All-Members Calls page.

This call will feature an overview of two new PGRN resources: the Pharmacogenomics iPSC Library and Service (PiLS) by Nao Terada and Pharmacogene Variation Consortium (PharmVar) by Andrea Gaedigk.  

​We will conclude with an open discussion period during which you can bring up any item of interest.

Not yet a member?  Apply for PGRN membership today by clicking here.

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  • Home
  • What is PGRN?
  • Members
    • Join
    • Members >
      • Member Research Interests
      • Members List
      • Members Directory
    • Apply for a Webpage
    • Research Pages >
      • African American Pharmacogenomics
      • Clinical Implementation of PGx
      • I-PICC: Integrating Pharmacogenetics in Clinical Care
      • Genetics of Israeli Populations (NLGIP)
      • GeT-RM PGx
      • Metformin PGx
      • MT-targeting agents
      • PEGASUS: Personalizing Emergency/Acute Therapeutics Utilizing Systems Biology
      • PGx of AIWG
      • PGx of Chemotherapeutic Toxicities
      • PGx of Statin Therapy
      • Precision Medicine In Leukemia
      • Predicting Drug Action
      • ...More Pages Coming Soon
    • Partner PGx Organizations >
      • UKPSMN
      • UPGx
    • Communities >
      • MetGen
    • Leadership
  • Data & Tools
    • GWAS Statistics >
      • RIKEN GWAS Statistics
    • Tools
  • PGRN Resources
    • Clinical Implementation
    • Functional Pharmacogenes
    • PGRN Hub
    • PGRN-PiLS Resource
    • PGRN-RIKEN >
      • RIKEN Publications
      • RIKEN Investigators
      • RIKEN Projects
    • PharmGKB
    • PharmVar
    • RPGEH
  • News
    • Event Calendar
    • PGX News
    • Featured Investigators
    • PGRN Recorded Talks
    • All PGRN Publications
  • Meetings
    • Monthly Member RIPS
    • All-Members Calls
    • Upcoming PGRN Meetings >
      • Poster Session at ASCPT 2019
      • CPIC® Meeting 2019
    • Past PGRN Meetings >
      • ASHG 2018
      • ASHG 2017
      • CPIC® Meeting 2017
      • ASHG 2016
      • Annual PGRN meeting at ASCPT 2016
      • 2015 PGRN All PIs Retreat
    • Other PGx Meetings