Launched in 2014, the NIH Common Fund’s Illuminating the Druggable Genome (IDG) Program enables researchers to explore understudied proteins with the potential to be modified by medicines. In November, a request for grant applications moved IDG into its implementation phase. The program plans to allocate $54 million to advance research through the development, broad dissemination, and use of community scientific resources to study human proteins for which publicly available information or active research is lacking. IDG aims to catalyze the discovery of novel biology, with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory G-protein-coupled receptor (GPCR) families. The program is administered by NIDDK, the National Center for Advancing Translational Sciences and the National Cancer Institute: https://commonfund.nih.gov/idg/index
This one-day symposium is organized by the Clinical Pharmacogenetics Implementation Consortium (CPIC ® ) as part of the Pharmacogenomics Research Network (PGRN) Symposium. Talks by world-class speakers from high profile academic, hospital and health service organizations will highlight how the USA and other countries are leading the way in strategizing the implementation of pharmacogenetics. This event will provide a great opportunity to meet with speakers from all sectors involved in pharmacogenetic implementation who will share their strategies and perspectives and provide tough examples for implementation. Further details and the registration link will soon be available here.
Location: Washington Marriott Wardman Park, Washington, DC, USA
Three main sessions and two panel discussions (see full agenda here):
Session I: Strategies for Implementing Pharmacogenetics
The Pharmacogenomics iPSC (induced Pluripotent Stem Cell) Library and Service (PiLS) is the latest resource that was funded by NIGMS Enabling Resources for Pharmacogenomics (R24) mechanism. Together with the other PGRN Centers and Resources, PiLS is the first resource that provides PGRN members with the iPSC Library and Service to enable pharmacogenomics studies.
PiLS is planning to roll out a pilot service to generate gene targeted iPSC clones for up to three selected projects. Projects will be recruited through announcement in NIGMS website as well as pgrn.org (join PGRN member to get e-mail about all PGRN announcements). PiLS iPSC library will be generated from genotyped healthy control samples of a cell bank established at the University of Florida. This original cell bank was established from salvaged samples from the Type 1 Diabetes Genetics Consortium (T1DGC), an international consortium established to identify the genes and alleles that contribute to risk for Type 1 Diabetes (T1D). The biosamples to be used were recruited with informed consent as part of the NIDDK/NIAID/NHGRI/NICHD supported Type 1 Diabetes Genetics Consortium (T1DGC). The iPSC library has integrated SNP database that could provide PGRN researcher practical and accessible methods to study potential impact of SNPs on drug response. The proposed resources are found at the PiLS webpage.
If you plan to use iPSC for your research anytime soon or are using iPSC for your research, please help to take this on-line survey or to include your feedback or comment about the PiLS resource. Based on your comments and research feasibility, PiLS could roll out the pilot service to tailor general needs. If you prefer to send in your comments and feedback or questions by e-mail, please send to Dr. Katherine E. Santostefano, email@example.com and firstname.lastname@example.org.
The Hub team