The Pharmacogenomics iPSC (induced Pluripotent Stem Cell) Library and Service (PiLS) is the latest resource that was funded by NIGMS Enabling Resources for Pharmacogenomics (R24) mechanism. Together with the other PGRN Centers and Resources, PiLS is the first resource that provides PGRN members with the iPSC Library and Service to enable pharmacogenomics studies.
PiLS is planning to roll out a pilot service to generate gene targeted iPSC clones for up to three selected projects. Projects will be recruited through announcement in NIGMS website as well as pgrn.org (join PGRN member to get e-mail about all PGRN announcements). PiLS iPSC library will be generated from genotyped healthy control samples of a cell bank established at the University of Florida. This original cell bank was established from salvaged samples from the Type 1 Diabetes Genetics Consortium (T1DGC), an international consortium established to identify the genes and alleles that contribute to risk for Type 1 Diabetes (T1D). The biosamples to be used were recruited with informed consent as part of the NIDDK/NIAID/NHGRI/NICHD supported Type 1 Diabetes Genetics Consortium (T1DGC). The iPSC library has integrated SNP database that could provide PGRN researcher practical and accessible methods to study potential impact of SNPs on drug response. The proposed resources are found at the PiLS webpage.
If you plan to use iPSC for your research anytime soon or are using iPSC for your research, please help to take this on-line survey or to include your feedback or comment about the PiLS resource. Based on your comments and research feasibility, PiLS could roll out the pilot service to tailor general needs. If you prefer to send in your comments and feedback or questions by e-mail, please send to Dr. Katherine E. Santostefano, firstname.lastname@example.org and email@example.com.
The Hub team