Read-me file accompanying the summary statistics of the genome-wide association study (GWAS) for allopurinol response. This study was coordinated by Deanna Brackman, Christopher C. Wen, Sook Wah Yee and Kathleen M. Giacomini. The summary statistics file contains the following information: SNPID - the SNP identifier as per the HapMap2 reference panel Chr - chromosome Pos_hg18 - position of the SNP on the chromosome, based on the hg18 Effect_Allele(A1) - the allele for which the beta and effect allele frequency are provided Other_Allele(A2) - the alternative, non-effect allele GWAS_Beta(A1) - the effect size in uric acid level change from baseline (mg/dL) GWAS_Beta_SE - standard error of the beta in uric acid level change from baseline (mg/dL) GWAS_Beta_95L - Lower bound of 95% confidence interval for beta GWAS_Beta_95U - Upper bound of 95% confidence interval for beta N - the sample size available for the SNP; up to 1,435 individuals GWAS_P - the p-value for association of the SNP with allopurinol-induced uric acid change Please see our publication for more information: Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM Clin Pharmacol Ther. 2015 May;97(5):518-25. PubMed: 25676789; PubMed Central: PMC4479153; DOI: 10.1002/cpt.89 --------------- Last updated on the 10th of April 2017 ---------------