README accompanying the summary statistics of the GWAS for cisplatin-associated ototoxicity (CAO). The summary statistics file contains the following information: CHR - chromosome SNP - rsID number BP_hg19 - position of the SNP on the chromosome, hg19 reference Effect_Allele(A1) - the allele for which the beta and allele frequency are provided Other_Allele(A2) - the alternative, non-effect allele A1_FRQ - frequency of A1 in the GWAS cohort (n = 511) BETA - the effect size of the normalized CAO phenotype (negative is increased risk of CAO) SE - standard error of the beta P - the p-value for association of the SNP with CAO Please see our publication for more information: Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Wheeler HE, Gamazon ER, Frisina R, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox N, Dolan ME, Travis L. Clinical Cancer Research 2016 Dec 30. PMID: 28039263 DOI: 10.1158/1078-0432.CCR-16-2809 --------------- Last updated on 2017-04-21 ---------------