Our Objective

The mission of the Pharmacogenomics Global Research Network (PGRN) is to catalyze and lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects.

Who We Were

PGRN IV was established July 1, 2015, and represented a continuation of research activities, however in a new model. The model invited participation of all investigators with an interest in pharmacogenomics research to be part of a network.

Then a new PGRN was formed to consist of three large center grant projects, two enabling resources for pharmacogenomics, a knowledgebase, PharmGKB, and a PGRN Hub, established to coordinate activities of the PGRN in order to catalyze research in pharmacogenomics and precision medicine.

Origins of Pharmacogenetics

Our History

Click here for the PGRN History.pdf

The Pharmacogenomics Research Network, PGRN I–III was funded from 2000 through 2015 by multiple Institutes and Centers of the NIH. The network catalyzed pharmacogenomics discoveries both nationally and internationally through the conduct of collaborative research focused on the discovery and translation of the genetic determinants of drug response, in order to enable safer and more effective drug therapies. 



Pharmacogenomics Knowledgebase

The PharmGKB is a resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships.


CPIC’s goal is to address some of the barriers to implementation of pharmacogenetic tests into clinical practice.


Pharmacogene Variation Consortium

PharmVar serves as a central repository for pharmacogene variation to facilitate allele (haplotype) designation and the interpretation of pharmacogenetic test results to guide precision medicine.

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