Our Objective

The mission of the Pharmacogenomics Research Network (PGRN) is to catalyze and lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects.
  • Member Benefits
  • Resources
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  • Access to exclusive resources
  • Opportunities to present research at monthly web conferences, national meetings, in poster sessions, and with a webpage at pgrn.org
  • Networking with experts
  • Chance to assist with planning scientific programs

Pharmacogenomics Knowledgebase (PharmGKB)
​The PharmGKB is a resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships.

Clinical Pharmacogenomics Implementation (CPIC)
CPIC’s goal is to address some of the barriers to implementation of pharmacogenetic tests into clinical practice.

Pharmacogenomics iPSC Library & Services (PiLS)
The PiLS is the first resource of its kind that provides PGRN members the ability to access and contribute towards iPSC library for pharmacogenomics research. ​

Functionalization of Variants in Clinically Actionable Pharmacogenes (F-CAP)
Our resource F-CAP will test all possible substitutions at all amino acid residues in some of the most clinically important pharmacogenes and disseminate these data to the medical and research communities.

PGRN-Hub Supported Resources

Access key resources supported by PGRN-Hub that will support the conduct of collaborative projects including PGRN-RIKEN, BioBank Japan and the RPGEH (click the links learn about the application processes).

Tools & Data

​The PGRN-Hub also catalogs a broad set of tools and databases, which can aid in the analysis and interpretation of pharmacogenomics research data.  Explore the Tools page here:

Who We Are

A new PGRN, PGRN IV, established July 1, 2015, represents a continuation of these research activities, however in a new model. This new model invites participation of all investigators with an interest in pharmacogenomics research to be part of the new network.

Currently, the newly formed PGRN consists of three large center grant projects, two enabling resources for pharmacogenomics, a knowledgebase, PharmGKB, and a PGRN Hub, established to coordinate activities of the new PGRN in order to catalyze research in pharmacogenomics and precision medicine.

Our History

The Pharmacogenomics Research Network, PGRN I–III was funded from 2000 through 2015 by multiple Institutes and Centers of the NIH. The network catalyzed pharmacogenomics discoveries both nationally and internationally through the conduct of collaborative research focused on the discovery and translation of the genetic determinants of drug response, in order to enable safer and more effective drug therapies.