Manuscripts published by the IWG

1. Cavallari LH, Hicks JK, Patel JN, Elchynski AL, Smith DM, Bargal SA, Fleck A, Aquilante CL, Killam SR, Lemke L, Ochi T, Ramsey LB, Haidar KE, Ho T, El Rouby N, Monte AA, Allen JD, Beitelshees AL, Bishop JF, Bousman C, Campbell R, Cicali EJ, Cook KJ, Duong B, Tsermpini EE, Girdwood ST, Gregornik DB, Grimsrud KN, Lamb N, Lee JC, Lopez RO, Mazhindu TA, Morris SA, Nagy M, Nguyen J, Pasternak AL, Petry N, van Schaik RHN, Schultz A, Skaar TC, Al Alshaykh H, Stevenson JM, Stone RM, Tran NK, Tuteja S, Woodahl EL, Yuan LC, Lee CR. The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation. Pharmacogenet Genomics. 2025 Jan; 35(1): 1-11. PMID: 39485373. PubMed link




2. Tuteja S, Hicks JK, Cavallari LH, El Rouby N, Smith DM, Patel JN, Hertz DL. Leveraging implementation science to enhance the adoption of DPYD testing. Pharmacogenet Genomics. 2025 Dec 16: doi: 10.1097/FPC.0000000000000581.PMID: 41396266. PubMed link




3. El Rouby N, Aquilante CL, Bargal SA, Cavallari LH, Duarte JD, Gunderson K, Mazhindu T, Nagy M, Nie X, D. Nguyen G, Patel JN, Skaar TC, Smith DM, Tuteja S, van Schaik RHN, Hicks JK. Global investigation of clinical implementation strategies for DPYD testing to guide fluoropyrimidine therapy. Clin Transl Sci. 2026 Jan;19(1):e70466. PMID: 41456101. PubMed link

Current Projects

1. Landscape survey-  A comprehensive survey distributed to all PGRN members assessing nine domains related to pharmacogenetic implementation: program characteristics; program infrastructure; pharmacogenetic test characteristics; patient populations; electronic health record (EHR) integration; clinical services; funding and billing; ethical, legal, and social issues (ELSI); and educational efforts. 

   Leads: Max Smith and Amanda Elchynski

2. Pediatric-focused survey- This analysis will focus on the resources required to implement pharmacogenomics in pediatric-focused clinics.

   Lead: Laura Ramsey

3. Strategies for DPYD-fluoropyrimidine implementation – This global survey aims to collect implementation outcomes and strategies for implementing DPYD and UGT1A1 testing

   Leads: Kevin Hicks and Nihal El Rouby

4. Tacrolimus implementation strategies- This global survey aims to collect strategies for implementing pharmacogenetic testing for tacrolimus in transplant recipients. The survey aims to summarize the different pharmacogenetic testing approaches, result interpretation and return, personalized tacrolimus dosing recommendations, and clinician education used at these institutions. The survey will also evaluate how sites have implemented some unique considerations for tacrolimus pharmacogenetics, including the transplant type, tacrolimus formulation, and non-genetic dose considerations.

   Leads: Amy Pasternak and Chris Aquilante

5. CYP2C19 for neurovascular indications- This survey is collecting strategies from centers implementing CYP2C19 testing to guide antiplatelet prescribing following neurovascular indications

   Lead: Rachael Stone

6. Direct-to-consumer testing project – This global survey will characterize the attitudes, perceptions, and current experiences of healthcare professionals with patients who have undergone DTC-PGx. It will explore any patient referrals that may have resulted from this testing, and the roles healthcare professionals play in the process. Additionally, it will assess their perspectives on integrating DTC-PGx testing into the healthcare system and identify best practices for its effective use. Participants will have the opportunity to share insights on consultations and institutional policies essential to the successful integration of DTC-PGx testing.

   Leads: Evangelia Eirini Tsermpini and Mohamed Nagy

7. Implementation Mapping Project- To identify core functions and forms for implementing pharmacogenomic testing in primary care clinics and to create a menu of user-informed, theory-based, implementation strategies.

   Lead: Sony Tuteja

8. PGx clinics- To characterize and collect strategies for delivering pharmacogenomics through a dedicated pharmacogenomic clinic.

   Leads: Emily Cicali and Natasha Petry

9. EHR Alert Language for Pediatrics- This survey will collect data from centers on the EHR alerts created for CPIC recommendations for pediatric patients.

   Lead: Tyler Shugg

10. Education strategies- This project will address one of the major obstacles to PGx implementation, namely, the education of healthcare providers. It will assess published review articles related to PGx education and conduct an umbrella review.

    Lead: Nancy Hakooz

11. DPYD payer project- The objective of this project is to identify barriers to DPYD testing authorization and reimbursement and develop strategies to overcome these barriers. Ongoing initiatives include 1) cataloging payers who are denying DPYD testing insurance claims; 2) developing templates for sites to appeal payers’ denial of DPYD testing; 3) creating a centralized strategy to advocate for and promote universal authorization and coverage for DPYD testing as a medically necessary test.

    Leads: Dan Hertz and Jai Patel

Please note that you need to be a PGRN Member to take part in this initiative.

PGRN Implementation Working Group - Collaborative Agreement