Below is the summary statistics file for allopurinol induced uric acid reduction in 1,495 patients for gout treatment. The sample size and precision of the data presented should preclude de-identification of any individual subject. However, in downloading these data, do not attempt to de-identify individual subjects.
Allopurinol response GWAS summary statistics txt file READ mePlease cite:
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer, C, Risch N, Giacomini KM. Clin Pharmacol Ther. 2015 May;97(5):518-25.
PubMed: 25676789; PubMed Central: PMC4479153; DOI: 10.1002/cpt.89.
Below is the summary statistics file for anti-hypertensive drug treatment-induced risk for new-onset diabetes in 552 European Americans, 471 Hispanics and 117 African Americans. The sample size and precision of the data presented should preclude de-identification of any individual subject. However, in downloading these data, you do not attempt to de-identify individual subjects.
As the dataset is quite large and exceed the storage limit (files in ~200Mb range), please contact info@pgrn.org to obtain the following txt files:
New-Onset Diabetes – European txt file New-Onset Diabetes – African txt file New-Onset Diabetes – Hispanics txt file New-Onset Diabetes – Meta-Analysis txt file READ mePlease cite:
Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.
Chang SW et al. Pharmacogenomics J. 2016 Sep 27
Pubmed: 27670767; PubMed Central: PMC5368017; DOI: 10.1038/tpj.2016.67
When using data from the downloadable results please acknowledge the source of the data as follows:
"The GWAS data was contributed by PGRN-RIKEN Investigators and was downloaded from www.pgrn.org/gwas-statistics.html".
In addition to the above acknowledgement, please cite the relevant paper.
Below is the summary statistics file for cisplatin-associated ototoxicity in 511 patients. The sample size and precision of the data presented should preclude de-identification of any individual subject. However, in downloading these data, you do not attempt to de-identify individual subjects.
Cisplatin ototoxicity GWAS summary statistics txt file READ mePlease cite:
Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity.
Wheeler HE et al. Clin Cancer Res. 2016 Dec 30