"Pharmacogenetics of Antidepressants in Pediatric Patients with Anxiety and Depression"
Dr. Ramsey is the Co-Director of the Genetic Pharmacology Service at Cincinnati Children’s Hospital Medical Center, which offers pharmacogenetic tests to patients and provides interpretation of results. She will present on the retrospective studies of pediatric patients with pharmacogenetic test results that were treated with antidepressants. Her lab found that pharmacogenetic phenotypes were associated with response, tolerability, and length of hospitalization in children with anxiety and/or depression treated with escitalopram, sertraline, and fluoxetine. They also performed pharmacokinetic modeling of escitalopram and sertraline based on CYP2C19 phenotypes to predict doses that would provide equivalent exposure across CYP2C19 phenotypes.
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