The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships. PharmGKB collects, curates and disseminates knowledge about the impact of human genetic variation on drug responses through the following activities:

• Annotate genetic variants and gene-drug-disease relationships via literature reviews
• Summarize important pharmacogenomic genes, associations between genetic variants and drugs, and drug pathways
• Curate FDA , EMA, PMDA, and HCSC drug labels containing pharmacogenomic information
• Enable consortia examining important questions in pharmacogenomics
• Curate and participate in writing pharmacogenomic-based drug dosing guidelines
• Contribute to clinical implementation projects for pharmacogenomics through collaborations
• Publish pharmacogenomic-based drug dosing guidelines, very important pharmacogene summaries and drug-centered pathways
• Display all information on the website and provide comprehensive downloads