About PharmGKB

The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical information including dosing guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships. PharmGKB collects, curates and disseminates knowledge about the impact of human genetic variation on drug responses through the following activities:

  • Annotate genetic variants and gene-drug-disease relationships via literature reviews
  • Summarize important pharmacogenomic genes, associations between genetic variants and drugs, and drug pathways
  • Curate FDA , EMA, PMDA, and HCSC drug labels containing pharmacogenomic information
  • Enable consortia examining important questions in pharmacogenomics
  • Curate and participate in writing pharmacogenomic-based drug dosing guidelines
  • Contribute to clinical implementation projects for pharmacogenomics through collaborations
  • Publish pharmacogenomic-based drug dosing guidelines, very important pharmacogene summaries and drug-centered pathways
  • Display all information on the website and provide comprehensive downloads


Teri E. Klein, PhD

CoPI & Director, PharmGKB



Russ B. Altman, MD PhD

The Kenneth Fong Professor of Engineering

Professor, Bioengineering, Genetics, & Medicine



Tiffany Murray

Genetics & Medicine

Shriram Center


Type of Award: R24

Grant Number: 1 R24 GM061374-16

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